Neural cue reactivity and intrinsic functional connectivity in individuals with alcohol use disorder following treatment with topiramate or naltrexone.

ABSTRACT:

Rationale

Both topiramate and naltrexone have been shown to affect neural alcohol cue reactivity in alcohol use disorder (AUD). However, their comparative effects on alcohol cue reactivity are unknown. Moreover, while naltrexone has been found to normalize hyperactive localized network connectivity implicated in AUD, no studies have examined the effect of topiramate on intrinsic functional connectivity or compared functional connectivity between these two widely used medications.

Objective

This study compared topiramate versus naltrexone on alcohol cue-elicited brain activation and intrinsic functional connectivity in patients with alcohol use disorder.

Methods

Forty-seven participants with alcohol use disorder received daily topiramate (titrating the dose up to 200 m

SUBMITTER: Logge WB 

PROVIDER: S-EPMC12226611 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature