Analysis of prognostic factors affecting TA-TMA patients: a single-center retrospective study.

ABSTRACT:

Objective

Transplantation-associated thrombotic microangiopathy (TA-TMA) is a severe thrombotic complication that occurs after hematopoietic stem cell transplantation. Currently, there are no clear conclusions on the factors influencing the prognosis of TA-TMA patients and the best treatment plan for TA-TMA.

Methods

We retrospectively collected information on 26 patients with TA-TMA from a single center. The independent factors affecting prognosis were analyzed through univariate and multivariate Cox regression. Subgroup analysis was also conducted to investigate the impact of different treatment methods on overall survival of patients.

Results

We found that high creatinine levels during the diagnosis of TA-TMA and previous CAR-T cell therapy were independent risk fac

SUBMITTER: Liu J 

PROVIDER: S-EPMC12226656 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature