A subcellularly targeted photocaged inhibitor for mitochondrial carbonic anhydrase V.

ABSTRACT: We report the first photoactivatable inhibitor specifically targeting mitochondrial CA-V, a promising anti-obesity target. It features a sulfonamide metal-binding group caged with a photoremovable coumarin and guided to mitochondria via a pyridinium moiety. Light exposure removes the cage, enabling precise spatial and temporal inhibition of mitochondrial CA-V activity.

SUBMITTER: Mafy NN 

PROVIDER: S-EPMC12226970 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature