Polygenic Risk Prediction for Normal-Tension Glaucoma.

ABSTRACT: Normal-tension glaucoma (NTG) is a subtype of glaucoma characterized by optic nerve damage in the setting of normal intraocular pressure. Polygenic risk scores (PRSs) have shown potential to assist with risk prediction in glaucoma, but to date no comprehensive studies have evaluated the predictive ability of PRSs for NTG. We utilized genome-wide association study (GWAS) summary data for NTG from a European cohort to estimate the variant weights and construct PRSs. The PRSs were computed using both the SBayesRC and clumping and thresholding (C+T) methods in 317 European ancestry NTG cases and 634 controls from the National Institutes of Health All of Us dataset. To validate our findings, we used the Genetics of Glaucoma (GOG) dataset for NTG cases (n = 89) and the QSkin Sun and Health Study

SUBMITTER: Marzban M 

PROVIDER: S-EPMC12227028 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature