Pt(IV)-functionalised polyacrylic acid-coated iron oxide magnetic nanoparticles as redox-responsive cancer theranostics.

ABSTRACT: Iron oxide nanoparticles represent a class of nanomaterials with unique physicochemical properties and high potential for theranostic applications. Herein, we functionalised polyacrylic acid (PAA)-coated iron oxide nanoparticles with a chemotherapeutic Pt(IV) prodrug, to prepare Fe₃O₄@PAA-Pt(IV) nanostructures that act as T₂ MR theranostics with redox- (and thus TME-) responsive therapeutic properties. The synthesis of Fe₃O₄@PAA-Pt(IV) nanoparticles was optimised to yield nanoparticles with appropriate hydrodynamic diameter and Pt/Fe ratio. The Fe₃O₄@PAA-Pt(IV) nanoparticles displayed promising magnetic and relaxometric properties, showing a higher relaxivity than commercially available NP-based MRI agent R

SUBMITTER: Brito B 

PROVIDER: S-EPMC12227113 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature