Cause-specific mortality in patients with steatotic liver disease in the United States.

ABSTRACT:

Background & aims

Causes of death across steatotic liver disease (SLD) subtypes remain incompletely characterized in routine clinical practice. We aimed to quantify and compare cause-specific mortality in patients with SLD.

Methods

We conducted a retrospective cohort study of adults with imaging-confirmed hepatic steatosis receiving outpatient care in the national Veterans Health Administration (2010-2021). The primary exposure was SLD subtype, including metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-associated liver disease (ALD), and their intersection (MetALD). The primary outcome was cause-specific mortality, stratified by baseline cirrhosis.

Results

Among 366,433 adults (mean age, 60.5 years; 7.7% female; 67.6% non-Hispanic White), 77.9

SUBMITTER: Ochoa-Allemant P 

PROVIDER: S-EPMC12227146 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature