Platelet transfusion induces transfusion-associated circulatory overload in rats with myocardial infarction.

ABSTRACT:

Background

Transfusion-associated circulatory overload (TACO) accounts for 35% of transfusion-related fatalities. Previous pre-clinical studies explored plasma and red blood cell transfusion in TACO, but the effect of platelets remains unexplored. Platelet transfusions have the highest rate of adverse reactions and are associated with increased mortality in TACO patients. We aimed to determine whether platelet transfusion induces circulatory overload compared to crystalloids and whether it causes a more severe phenotype than plasma in a TACO rat model of myocardial infarction (MI).

Methods

A validated TACO model in anemic Wistar rats with MI was used. Animals received platelets (n = 11), plasma (n = 10), or Ringer's lactate (n = 11). Pulmonary capillary pressure was assessed

SUBMITTER: Phelp PG 

PROVIDER: S-EPMC12227162 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature