Breath Analysis of Propofol and Associated Metabolic Signatures: A Pilot Study Using Secondary Electrospray Ionization-High-resolution Mass Spectrometry.

ABSTRACT:

Background

Propofol is a widely used anesthetic for total IV anesthesia. Although it is generally safe, rare but serious complications can occur in vulnerable groups, such as critically ill patients and children. Clinicians often rely on surrogate measures ( e.g. , predicted effect-site concentrations or Bispectral Index), yet more direct indicators of anesthetic exposure and metabolic stress would be valuable. The authors hypothesized that pharmacometabolomics via breath analysis could yield real-time insights into propofol concentrations as well as accompanying metabolic responses to surgery.

Methods

In this pilot study, 10 pediatric patients (median age, 5.9 yr; interquartile range, 4.3 to 6.6) undergoing propofol anesthesia contributed 47 breath samples (10 preinduction,

SUBMITTER: Zeng J 

PROVIDER: S-EPMC12227210 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature