Host Biomarkers and Antibiotic Tissue Penetration in Sepsis: Insights from Moxifloxacin.

ABSTRACT:

Background and objective

Sepsis-induced pathophysiological changes may lead to pharmacokinetic variability which alters antibiotic concentrations at the host infection site. This poses a challenge in clinical practice, as sufficient antibiotic concentrations in tissue are necessary to effectively eradicate bacterial pathogens. In this exploratory study, we aimed to evaluate the potential of routinely used laboratory biomarkers to predict subcutaneous and muscle tissue penetration of moxifloxacin in septic patients.

Methods

We retrospectively analyzed data from 10 septic patients included in a pharmacokinetic study, in which moxifloxacin concentrations in subcutaneous adipose and muscle tissues were measured with microdialysis. We correlated the tissue-to-plasma ratio and pro

SUBMITTER: Sanz-Codina M 

PROVIDER: S-EPMC12227375 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature