Neural mechanisms of disease pathology and cognition in young-onset Alzheimer's disease variants.

ABSTRACT: BackgroundLate-onset Alzheimer's disease is consistently associated with alterations in the default-mode network (DMN)-a large-scale brain network associated with self-related processing and memory. However, the functional organization of DMN is far less clear in young-onset Alzheimer's disease (YOAD).ObjectiveThe current study aimed to identify effective connectivity changes in the core DMN nodes between YOAD variants and healthy controls.MethodsWe assessed resting-state DMN effective connectivity in two common YOAD variants (i.e., amnestic variant (n = 26) and posterior cortical atrophy (n = 13) and healthy participants (n = 24) to identify disease- and variant-specific connectivity differences using spectral dynamic causal modelling.ResultsPatients with the amnestic variant showed incre

SUBMITTER: Sacu S 

PROVIDER: S-EPMC12227830 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature