Association of glutamine metabolites in synovial fluid with the severity of temporomandibular joint osteoarthritis.

ABSTRACT:

Background

The aim of this study was to compare the levels of glutamine and its metabolites, including glutamate, glutaminase (GLS), and α-ketoglutarate (α-KG), in the synovial fluid (SF) of temporomandibular joint osteoarthritis (TMJ-OA) and temporomandibular joint internal derangement (TMJ-ID) patients. Correlations between these factors and TMJ-OA severity were assessed, and changes in these factors before and after hyaluronic acid (HA) treatment were analysed.

Methods

SF samples from 30 patients with unilateral TMJ-ID and unilateral TMJ-OA were analysed, along with visual analogue scale (VAS) scores, maximum mouth opening (MMO), and radiographic stages. The SF levels of glutamine, glutamate, GLS, and α-KG were determined via an enzyme-linked immunosorbent assay. Spearman

SUBMITTER: Song Z 

PROVIDER: S-EPMC12228145 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature