Neuroimaging and biological markers of different paretic hand outcomes after stroke.

ABSTRACT:

Background

Hand dysfunction significantly affects independence after stroke, with outcomes varying across individuals. Exploring biomarkers associated with the paretic hand can improve the prognosis and guide personalized rehabilitation. However, whether biomarkers derived from resting-state fMRI (rs-fMRI) can effectively classify and predict different hand outcomes and their biological mechanisms remain unclear.

Methods

This study analyzed 65 patients with chronic subcortical stroke, including 32 patients with partially paretic hand (PPH) and 33 patients with completely paretic hand (CPH). For patients with PPH and CPH respectively, the age was 56.19 ± 10.53 and 55.60 ± 9.00 years, disease duration was 15.31 ± 14.87 and 14.12 ± 17.36 months, lesion volume was 9.45 ± 5.57 an

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12228339 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature