Reprogramming of liver metabolism during West Nile virus infection unveils novel aspects of disease pathophysiology.

ABSTRACT:

Background

West Nile virus (WNV) is a neurotropic mosquito-borne flavivirus responsible for outbreaks of encephalitis and meningitis worldwide. About 20% of infected patients exhibit abnormal liver function tests, although the participation of this organ in the pathophysiology of the disease remains unclear. To fill this gap, this study explores changes in liver metabolism during WNV infection.

Methods

Given the relevance of the liver as a major immune and metabolic organ, the changes in response to WNV infection were analyzed in the mouse model combining transcriptomics, lipidomics and histopathological analyses.

Results

Despite the absence of detectable viral replication in the liver, infection resulted in hepatic transcriptomic reprogramming that affected inflammat

SUBMITTER: Mingo-Casas P 

PROVIDER: S-EPMC12228371 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature