Neurovascular coupling assessment by transcranial doppler in acute stroke could be informative of long-term cognitive status.

ABSTRACT: To assess whether Neurovascular Coupling (NVC) status in acute ischemic stroke predicts long-term cognitive impairment, this prospective study included consecutive ischemic stroke patients, without prior cognitive deficits, recruited between September 2021 and August 2022. Transcranial Doppler (TCD) monitoring was performed within 72 hours post-stroke to measure NVC, determined by peak relative increase in cerebral blood velocity (CBv) in the posterior cerebral artery (PCA) during a visual stimulus. Age-, gender-, and vascular risk factor-matched controls were included. The primary outcome was cognitive status at 12 months, evaluated using a 7-point cognitive scale. A total of 144 acute stroke patients and 40 controls were included. NVC exhibited a U-shaped association with long-term cogni

SUBMITTER: Ferreira J 

PROVIDER: S-EPMC12228646 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature