Cognitive reserve in multiple sclerosis: The role of depression and fatigue.

ABSTRACT:

Background

Several reports suggest that cognitive reserve (CR) may protect against cognitive impairment in MS. Fatigue and depression are common in MS. Yet, their influence on engagement with activities that build CR is unclear.

Objectives

This study aimed to achieve a better understanding of CR-building in MS, by examining how CR differs in people with MS (pwMS) compared with neurologically healthy individuals and by investigating how common MS symptoms interact with CR-building.

Methods

In total, 206 pwMS and 150 age- and gender-matched controls participated in this cross-sectional study. Participants completed self-report measures of CR accumulated in early life and across the lifespan (including education, occupation, cognitively enriching leisure activities), and

SUBMITTER: Stein C 

PROVIDER: S-EPMC12228891 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature