We should do better in accounting for multiple births in neonatal randomised trials: a methodological systematic review.

ABSTRACT:

Objective

To conduct a methodological systematic review of multicentre trials of premature infants to (1) determine if and how multiple births have been considered in the design, analysis and reporting of recent trials and (2) assess whether there has been an improvement since the last review was conducted 10 years ago.

Design

A systematic search was conducted in PubMed on 28 June 2023 for articles published between June 2018 and June 2023. Articles were eligible for inclusion if they were a multicentre randomised trial of infants born preterm and reported the results of a primary outcome that was measured on an infant or could be attributed to an infant.

Results

We reviewed 62/74 trials (80%), after determining it was unclear if multiple births were present in the ot

SUBMITTER: Robledo KP 

PROVIDER: S-EPMC12229078 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature