Associations of fetal and infant growth with pubertal timing.

ABSTRACT:

Objective

Impaired fetal and infant growth may cause alterations in developmental programming of the hypothalamic-pituitary-gonadal axis and subsequently pubertal development. We aimed to assess associations between fetal and infant growth and pubertal development.

Design

Population-based prospective birth cohort.

Setting

Rotterdam, the Netherlands.

Patients

5830 singleton born children.

Interventions

We estimated fetal weight in second and third trimester by ultrasound. Infant growth measures were gestational age and weight at birth and infant weight at 6, 12 and 24 months.

Main outcome measures

Pubertal timing outcomes included difference between chronological and skeletal age assessed using dual-energy X-ray absorptiometry, testicular or ovaria

SUBMITTER: Blaauwendraad S 

PROVIDER: S-EPMC12229080 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature