Three-dimensional composite aerogel scaffolds based on electrospun poly(lactic acid)/gelatin and silica-strontium oxide short fibers promote bone defect healing.

ABSTRACT:

Background

Bone defect regeneration is a dynamic healing process that relies on the body's innate repair mechanisms, yet natural healing capacity remains limited. To address this challenge, advanced biomaterials combining bioactive inorganic components with biocompatible polymers have emerged as a promising strategy to enhance osteogenesis and angiogenesis.

Methods

In this study, a novel three-dimensional composite scaffold material was successfully fabricated using a combined electrospinning-freeze drying technique. The scaffold incorporates flexible silicon dioxide-strontium oxide (SiO₂-SrO) nanofibers as functional components, which are physically blended with a poly(lactic acid)/gelatin (PG) fibrous matrix to achieve composite construction.

Result

The f

SUBMITTER: Cui J 

PROVIDER: S-EPMC12229089 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature