Effect of Time Delay on Reperfusion After Tenecteplase in an Extended Time Window: Analysis From the CHABLIS-T Trials.

ABSTRACT:

Background

The association between time and reperfusion in an extended time window remains unexplored. This study aimed to investigate whether time delay was associated with reduced odds of reperfusion in patients with acute ischemic stroke treated with tenecteplase in the 4.5- to 24-hour time window, in the CHABLIS-T (Chinese Acute Tissue-Based Imaging Selection for Lysis in Stroke-Tenecteplase) trials.

Methods

Patients from the CHABLIS-T and CHABLIS-T II trials treated with tenecteplase were included. Major reperfusion was assessed via follow-up perfusion imaging or digital subtraction angiography. Time intervals from symptom onset/last known well to hospital arrival/administration of tenecteplase were analyzed as continuous and categorical variables in multivariable logis

SUBMITTER: Hong L 

PROVIDER: S-EPMC12229177 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature