Nanostructured organic sheets sequestering small extracellular vesicles and reactive species to protect against radiation-induced mucositis.

ABSTRACT: Radiation-induced mucositis significantly reduces quality of life in patients undergoing radiotherapy and chemoradiotherapy for head and neck cancer. Radiation exposure increases the secretion of small extracellular vesicles carrying double-stranded DNA, which triggers excessive inflammation. To address this, we develop functionalized organic nanosheets designed to capture these inflammatory vesicles from damaged tissue. Using template-based synthesis, we create nanostructured organic sheets functionalized with CD63 aptamers, enabling selective targeting of extracellular vesicles involved in mucositis. These nanosheets show enhanced vesicle-binding capacity compared to spherical nanoparticles, efficiently suppressing inflammation by inhibiting the stimulator of interferon genes activation

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12229327 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature