The role of JPT1 in hepatocellular carcinoma: tumor progression, microtubule dynamics regulation, and potential mechanisms within the immune microenvironment.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a highly prevalent and lethal malignancy worldwide, with its progression and metastasis significantly impacting patient prognosis. JPT1 (Jupiter microtubule-associated homolog 1), a novel microtubule-associated protein, has been implicated in regulating cytoskeletal stability, microtubule dynamics, and the immune microenvironment, thereby potentially driving HCC development and progression. However, the precise role and underlying mechanisms of JPT1 in HCC remain poorly understood.

Methods

This study integrated data from TCGA-LIHC and GEO (GSE14520) databases to systematically investigate the expression profile of JPT1 and its association with clinicopathological features and prognosis in HCC patients. A pan-cancer analysis was pe

SUBMITTER: Lu Y 

PROVIDER: S-EPMC12229377 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature