Characteristics of the integration sites and module structures of the Tn916 and its family.

ABSTRACT: Tn916, the most typical conjugative transposon that contains the tetM resistance gene, has been identified in various genomes. This study examined the recognized Tn916 (with an identity of > 90%) and Tn916 other family members (with identities between 60 and 90%) in all currently known complete genome and chromosome sequences, naming them Tn916.1 to Tn916.9. Tn916 and other members of this family have similar structures: AT-rich inverted repeats (IRs), with the boundaries being AT-rich stem‒loop structures; the coupling sequences in the middle, often 5 bp AT-rich regions, with the conserved base is the first base A or the last base T; the stem sequence from the host, which often matches or complements part of the IR (4-5 bp). Most Tn916 family members have ABC transporter gene clusters as

SUBMITTER: Song L 

PROVIDER: S-EPMC12229494 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature