Discovery and molecular characterization of a potent thiazolyl-pyrazole hybrid targeting EGFR for breast cancer therapy.

ABSTRACT: Herein, a novel compound 2-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazolylidene)-3-phenylthiazolidin-5-one )2(was synthesized and reacted with different aromatic aldehydes 3a-f via Knoevenagel condensation reaction to give the corresponding 4-arylidene-2-(5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)thiazolidin-5-one hybrids 4a-f. The chemical structures were described by spectroscopic tools, IR, ¹H NMR, ¹³C NMR, and MS. Their frontier molecular orbitals configuration and electron distribution were estimated to utilize DFT. The cytotoxicity of thiazolyl-pyrazole analogues 2 and 4a-f demonstrated in vitro antitumor activity toward breast cells; MCF-7 and MDA-MB231. Among the prepared analogues, the thiazolyl-pyrazole 2 revealed potent inhibitory toward the two cancer cells

SUBMITTER: Mahmoud SE 

PROVIDER: S-EPMC12229662 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature