Epigenetic dysregulation-induced metabolic reprogramming fuels tumor progression in bladder cancer.

ABSTRACT:

Background

Bladder cancer remains a significant global health challenge with a high mortality rate despite advancements in treatment modalities. Metabolic alterations serve as crucial contributors to cancer progression, particularly influencing tumor aggressiveness and patient outcomes. Therefore, this study aimed to identify and characterize metabolic hubs associated with disease progression and tumor aggressiveness in bladder cancer.

Methods

DNA methylation, mRNA expression and protein expression, along with clinical data for bladder cancer patients were retrieved from TCGA database. Differentially expressed metabolic hubs among tumor aggressiveness groups and between early vs advanced stage tumors were identified using ANOVA and Student's t-test respectively, where

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12229847 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature