<i>CYLD</i> as a key regulator of myocardial infarction-to-heart failure transition revealed by multi-omics integration.

ABSTRACT:

Introduction

Heart failure (HF) is the most common complication following myocardial infarction (MI) and frequently occurs during the postinfarction recovery phase. Despite the well-established association between HF and MI, the underlying molecular mechanisms driving their transition remain poorly understood.

Methods

The aim of this study was to identify key regulatory genes involved in this transition via advanced computational tools. We conducted a comprehensive analysis of differentially expressed genes (DEGs) via Limma software, leveraging five independent datasets retrieved from the Gene Expression Omnibus (GEO) database: GSE59867, GSE62646, GSE168281, GSE267644, and GSE269269. Our multistep analytical pipeline included weighted gene coexpression network analysis (WGCN

SUBMITTER: Xu J 

PROVIDER: S-EPMC12229883 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature