Meta-analysis of muscle transcriptome data identifies key genes influencing intramuscular fat content in pigs.

ABSTRACT:

Objective

The content of intramuscular fat (IMF) is closely linked to meat quality, and the mechanism of IMF deposition is complex. Despite numerous transcriptomic studies on IMF, variations in sample sizes and data analysis methods have produced inconsistent gene expression patterns and results. To identify the pivotal genes influencing pig IMF content, we performed a meta-analysis on 10 pig muscle transcriptome datasets with a total of eighty samples, forty with high and forty with low IMF samples.

Methods

DESeq2 has been used to analyze the high and low IMF groups for 10 datasets each, resulting in the differentially expressed genes (DEGs) for each dataset. To identify key genes affecting IMF content, we performed a meta-analysis of the differential expression results fro

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12229906 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature