Barrier genes are associated with preterm birth.

ABSTRACT:

Background

Biological barriers are essential for maintaining integrity and function and preventing microbial invasion. Maternal barrier dysfunction may play a role in preterm birth (PTB). However, the link between maternal barrier function and PTB is still unknown. This study aims to identify genetic evidence supporting the role of maternal barrier genes in PTB risk.

Methods

We examined 201 barrier-related genes to assess their association with PTB susceptibility. We utilized the FinnGen study, published literature's whole-genome sequencing (WGS) summary statistics and Early Growth Genetics (EGG) meta-analysis to identify the maternal barrier gene associated with PTB.

Results

Findings from the analysis of the maternal genome highlighted several barrier genes (NOTCH

SUBMITTER: Chen KR 

PROVIDER: S-EPMC12230043 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature