Characterization of the clinical relevance and hypoallergenic peptides of the newly evidenced major allergen Hum j 1.

ABSTRACT:

Background

Humulus japonicus (HJ) pollen is a predominant autumn allergen in northern China. Two decades ago, a 10 kDa protein termed Hum j 1 was proposed as a major allergen, but its uncertainty hindered its clinical application. This study aims to investigate the clinical relevance of Hum j 1 and screen hypoallergenic peptides for potential application in molecular diagnosis and immunotherapy.

Methods

Serum samples from 93 HJ pollen-allergic patients were analyzed for IgE reactivity against recombinant Hum j 1 (rHum j 1). We evaluated correlations between IgE responses to rHum j 1 and HJ pollen crude extracts using Spearman's rank correlation analysis. The association between clinical symptoms and Hum j 1-IgE positivity was evaluated by group comparisons and multiva

SUBMITTER: Cheng YL 

PROVIDER: S-EPMC12230049 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature