Identification and validation of endoplasmic reticulum autophagy-related potential biomarkers in periodontitis.

ABSTRACT: Periodontitis is a chronic inflammatory disease that mainly occurs in the dental supporting tissues. Endoplasmic reticulum autophagy (ER-phagy) is a new type of selective autophagy. The main function of ER-phagy is to degrade excess ER membranes or toxic protein aggregates, control the volume of ER, and maintain cell homeostasis. This study utilized bioinformatics to identify and validate potential ER-phagy-related biomarkers for periodontitis. The relationship between immune cell infiltration and periodontitis as well as potential biomarkers was analyzed, to identify new targets for the diagnosis and treatment of periodontitis. Data from GeneCards and Gene Expression Omnibus (GEO) databases were utilized to identify differentially-expressed ER-phagy-related genes, and to conduct functiona

SUBMITTER: Wang R 

PROVIDER: S-EPMC12230163 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature