Multi-Omics Analyses Reveal Relationships Between Gut Microbiota and Frailty.

ABSTRACT:

Introduction

Observational studies suggest a strong association between gut microbiota and frailty, but the underlying mechanisms remain unclear. This study aimed to investigate potential causal links and biological pathways linking gut microbiota and frailty.

Methods

We utilized summary-level data of gut microbiota and frailty data from MiBioGen and a genome-wide association meta-analysis. A bidirectional, two-sample Mendelian randomization (MR) analysis was performed to investigate the causal relationship between gut microbiota and frailty. Additional genetic and genomic analyses were conducted to identify common biological pathways.

Results

We identified eight causal relationships between the gut microbiota composition and frailty. Inverse-variance weighting sugges

SUBMITTER: Hou X 

PROVIDER: S-EPMC12230348 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature