The Evolving Global Burden of Young-Onset Parkinson's Disease (1990-2021): Regional, Gender, and Age Disparities in the Context of Rising Incidence and Declining Mortality.

ABSTRACT:

Background

Young-onset Parkinson's disease (YOPD) has emerged as a significant global public health challenge characterized by its early onset among individuals in their prime working years, complex disruptions to social roles, and a substantial socioeconomic burden encompassing diminished productivity, escalating healthcare costs, and markedly reduced quality of life.

Methods

Using Global Burden of Disease (GBD) 2021 data, this study analyzed YOPD burden (ages 20-49) from 1990 to 2021, assessing age-standardized incidence rate (ASIR), mortality rate (ASMR), disability-adjusted life years rate (ASDR), and trends via Bayesian Age-Period Cohort (BAPC) modeling.

Results

Over the past three decades, the ASIR (estimated annual percentage change [EAPC] = 1.40%) and ASDR (EA

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12230373 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature