Electrochemically promoted defluorinative sulfoximination and fluorosulfonylation of non-activated aryl fluorides at room temperature.

ABSTRACT: Due to the high bond dissociation energy and kinetic inertness of the C-F bond, direct activation of inert aryl fluorides for new transformations under mild conditions remains a significant challenge. Although it has been known that single electron reduction can be applied for the activation of inert aryl fluorides at room temperature, the need for very strong reduction conditions along with the competitive side reactions during the reduction process limits the synthetic applications. Herein, by leveraging the advantages of electrosynthesis and the versatile transformation nature of aryl radicals, two types of challenging defluorinative transformations of non-activated aryl fluorides which include sulfoximination via cheap nickel catalysis and transition metal catalyst-free fluorosu

SUBMITTER: Kong X 

PROVIDER: S-EPMC12230856 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature