M2 macrophage-secreted KYNU promotes stemness remodeling and malignant behavior in endometrial cancer via the SOD2-mtROS-ERO1α-UPR^ER axis.

ABSTRACT:

Background

M2 macrophages are known to be involved in tumorigenesis. However, the mechanism by which they promote tumor progression in endometrial cancer (EC) remains largely unknown. Kynureninase (KYNU) has been found to be associated with the progression of various tumors, but research on endometrium is limited to embryo transfer. Therefore, a better understanding of KYNU as a potential therapeutic target in EC treatment is needed. This study aimed to elucidate the mechanism by which M2 macrophage-secreted KYNU influences the malignant biological and stemness remodeling of EC via the SOD2-mtROS-ERO1α and endoplasmic reticulum unfolded protein response (UPR^ER) pathway.

Methods

We used flow cytometry for cell sorting. Fluorescence experiments were conducted to rev

SUBMITTER: Pan X 

PROVIDER: S-EPMC12231660 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature