Proteomic associations with fluctuation and long-term changes in BMI: A 40-year follow-up study.

ABSTRACT:

Introduction

While some studies have explored associations between weight change and blood proteins, most have been intervention-based, offering limited insight into proteomic associations with long-term weight gain. It remains unclear whether plasma proteins are related to BMI fluctuation over time. This study investigates associations of long-term BMI changes and fluctuations with over 1000 plasma proteins involved in cardiometabolic and inflammation functions.

Data and methods

The study included 304 Finnish adult twins (117 men) born before 1958 from the Older Finnish Twin Cohort, with BMI data spanning five time points (1975, 1981, 1990, 2011 and 2012-2014). Proteomic data were derived from blood samples collected at the last BMI measurement. Linear mixed-effects models

SUBMITTER: Obeso A 

PROVIDER: S-EPMC12232349 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature