Intelligent Batch Epitope Identification and Partitioning: an intelligent tool for the identification of B cell dominant epitopes.

ABSTRACT: Identifying B cell dominant epitopes helps to improve vaccine design and better understand immune evasion of pathogens. Herein, we present the Intelligent Batch Epitope Identification and Partitioning (IBEIP), an intelligent tool for identifying B cell dominant epitope regions based on antigen-neutralizing antibody (Ag-nAb) complex data. IBEIP can accurately map the epitopes on any appointed Ag-nAb complex by analyzing antigen-antibody interactions at a molecular level. Combined with a hierarchical iterative merging model, IBEIP can intelligently merge and analyze mapped epitopes to identify B cell dominant epitopes. It is also applicable to analyzing high-mutant antigens and complex epitope structures. We demonstrated the performance of IBEIP by analyzing 127 Ag-nAb complexes from the res

SUBMITTER: Ma YF 

PROVIDER: S-EPMC12232423 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature