Comparing Soy and Milk Protein Regulation of Hepatic Omega-3 Fatty Acid Biosynthesis.

ABSTRACT: The omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have numerous benefits, including strong anti-inflammatory and triglyceride-lowering properties. EPA and DHA are primarily obtained by consuming fatty fish; however, they are also endogenously synthesized primarily in the liver from α-linolenic acid (ALA) through a pathway mediated by the delta-6 desaturase (D6D) enzyme. Previous reports in rodents and humans suggest that dietary proteins such as soy and dairy may impact this pathway differently. The primary aim was to investigate the effects of diets containing either soy or milk protein on the expression, abundance, and enzymatic activity of the desaturases and elongases regulating hepatic omega-3 fatty acid biosynthesis. Male C57BL/6N mice (n = 16 per gro

SUBMITTER: Gonzalez-Soto M 

PROVIDER: S-EPMC12232530 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature