Propranolol and Oxytocin-Induced Contractility in Gravid Human Myometrium: An Ex Vivo Laboratory Study.

ABSTRACT:

Objective

To determine the effect of propranolol on myometrial contractions induced by low dose and high dose oxytocin.

Design

Prospective ex vivo laboratory study.

Setting

Mount Sinai Hospital, Toronto.

Population

Full-term parturients who underwent elective caesarean deliveries (CD).

Methods

Two models were developed in the organ bath chamber using myometrial samples obtained during CDs: (i) Labor induction-augmentation model with low-dose oxytocin consisting of 3 groups with the administration of propranolol before and during simulated labor, and a control group. (ii) Postpartum haemorrhage (PPH) model with high-dose oxytocin consisting of 4 groups with the administration of propranolol during and/or after augmented labor (desensitised with oxytocin),

SUBMITTER: Balki M 

PROVIDER: S-EPMC12232598 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature