Investigating the potential antibacterial, anti-biofilm, wound healing and anti-inflammatory activity of the extract of Aspergillus niger endophyte isolated from cucumber leaves: in vitro and in vivo study.

ABSTRACT:

Background

Endophytic fungi are a vast inventory of bioactive compounds, offering potent, cost-effective, renewable, and low-toxicity alternatives for therapeutic applications. The current investigation focused on the endophytic fungus Aspergillus niger, which was isolated for the first time from Cucumis sativus (cucumber) leaves and subjected to comprehensive evaluation, including anti-inflammatory, antibacterial, anti-biofilm, and in vitro wound healing potential. 18 S rRNA gene sequencing was utilized to identify A. niger after isolation, and the fungus was cultivated on Asian rice to produce fungal metabolites. The high-resolution liquid chromatography-mass spectrometry (LC-HRESI-MS/MS) was then used to elucidate its phytochemical profile.

Results

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SUBMITTER: El-Bouseary MM 

PROVIDER: S-EPMC12232745 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature