Overexpression of TSG101 causes the development of adenosquamous mammary carcinoma.

ABSTRACT:

Background

The mammalian Tumor Susceptibility Gene 101 (TSG101) encodes a protein with diverse functions that control the proliferation and survival of cells, but its role in malignant transformation and cancer development has remained enigmatic.

Methods

To study the pro-tumorigenic functions of TSG101, we developed a bi-transgenic mouse model that expresses exogenous TSG101 along with a luciferase reporter in a ligand-controlled manner in the mammary gland epithelium. We performed a comprehensive histopathologic, biochemical, and molecular characterization of ductal hyperplasia and mammary tumors. Unsupervised hierarchical clustering based on 1,723 intrinsic genes of ten TSG101-overexpressing cancers alongside 251 tissue samples representing 31 reference mammary tumor model

SUBMITTER: Dennaoui R 

PROVIDER: S-EPMC12232759 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature