Immunoglobulin A/PIGR axis as potential mediators of human abdominal aortic aneurysms revealed by topologically resolved proteomics.

ABSTRACT:

Background

Abdominal aortic aneurysm (AAA) is an asymptomatic chronic disease of the aorta and its evolution is unpredictable. Despite the existence of several pathological mechanisms contributing to the dilation of the human AAA wall, there is currently no specific therapy to prevent the fatal rupture of the aorta. Our objective was to identify novel mediators and/or biomarkers involved in the instability of the aortic wall that could help to prevent AAA progression.

Methods

Multiplexed quantitative proteomic analysis of human AAA and healthy aortic wall (medial and adventitial layers) was performed. Results were subsequently validated by western blot and immunohistochemistry, as well as by turbidimetry/ELISA of tissue-conditioned media. In addition, immunoglobulins A1 and

SUBMITTER: Cerro-Pardo I 

PROVIDER: S-EPMC12232777 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature