Analysis of DNA microarrays using algorithms that employ rule-based expert knowledge.

ABSTRACT: The ability to investigate the transcription of thousands of genes concurrently by using DNA microarrays offers both major scientific opportunities and significant analytical challenges. Here we describe GABRIEL, a rule-based system of computer programs designed to apply domain-specific and procedural knowledge systematically and uniformly for the analysis and interpretation of data from DNA microarrays. GABRIEL'S problem-solving rules direct stereotypical tasks, whereas domain-specific knowledge pertains to gene functions and relationships or to experimental conditions. Additionally, GABRIEL can learn novel rules through genetic algorithms, which define patterns that best match the data being analyzed and can identify groupings in gene expression profiles preordered by chromosomal positio

SUBMITTER: Pan KH 

PROVIDER: S-EPMC122328 | biostudies-literature | 2002 Feb

REPOSITORIES: biostudies-literature