Alcohol consumption and DNA methylation: an epigenome-wide association study within the French E3N cohort.

ABSTRACT:

Background

Alcohol consumption can have harmful effects on health, depending on the quantity and frequency. Understanding the underlying molecular mechanisms is essential to grasp its health consequences. The study aimed to assess the association between alcohol consumption and blood DNA methylation, an epigenetic mechanism that controls gene expression.

Methods

The epigenome-wide association study (EWAS) included 1,538 women from a case-cohort study within the French E3N cohort. Weighted linear mixed-effects models were used to assess the associations between self-reported alcohol consumption (in g/day in 1993) and DNA methylation at 715,986 CpGs measured with the HumanMethylationEPIC Beadchip. Women were cancer-free at blood collection in 1995-1999.

Results

Of the 7

SUBMITTER: Dragic D 

PROVIDER: S-EPMC12232872 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature