Metabolic Alterations Associated With Rapidly Progressive Chronic Kidney Disease in Cats.

ABSTRACT:

Background

Chronic kidney disease (CKD) in cats often remains stable over time, but some cats experience progressive kidney dysfunction without an identifiable cause.

Objectives

Identify differences in serum and urine compounds related to tryptophan metabolism and gut-derived uremic toxins between cohorts with non-progressive and rapidly progressive CKD.

Animals

Forty-two client-owned cats diagnosed with CKD were divided into a rapid progression group (n = 8) and a non-progressive control group (n = 34).

Methods

Prospective cohort study with comparative analysis of predictors using targeted metabolomics. Rapid progression was defined as a 25% increase in serum creatinine concentration over 6 months.

Results

Serum metabolite ratios of the serotonin pathwa

SUBMITTER: van Mulders L 

PROVIDER: S-EPMC12232975 | biostudies-literature | 2025 Jul-Aug

REPOSITORIES: biostudies-literature