Association between shortened maternal and fetal telomere length and abnormal fetal development.

ABSTRACT: A number of intrinsic, maternal and environmental factors have been linked to the risk of fetal developmental anomalies. In a previous study, we showed that telomere length (TL) was notably reduced in amniotic fluid when the fetus exhibited a developmental anomaly. In this new study, we measured the fetal and maternal TL for 75 evolutive pregnancies with congenital malformation. We also measured the TL of 50 pregnant women without fetal anomalies and 50 non-pregnant control women who had at least one child with normal development. In fetal samples, telomeres were significantly shortened in cases with congenital anomalies compared to controls (n  =  93) (P  <  0.0001). Interestingly, age-adjusted maternal TL was also significantly reduced in these cases (P  <  0.01). Receiver operating char

SUBMITTER: Coudrieu O 

PROVIDER: S-EPMC12233292 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature