Neuropathological comorbidity, genetics and cognition in a Chinese community-based autopsy cohort.

ABSTRACT: Neurodegenerative comorbidities are common and critical, yet data specific to the Chinese population remains limited. In this study, we aimed to investigate the prevalence and associations of neuropathological changes and comorbidities and their correlation with genetics and cognition in a community-dwelling autopsy cohort in China. Datasets of 610 participants were obtained from the National Human Brain Bank for Development and Function at the Chinese Academy of Medical Sciences/Peking Union Medical College. Neuropathological changes analysed included: Alzheimer's disease neuropathological change (ADNC; n = 331); α-synucleinopathies (n = 124), including 120 Lewy body disease (LBD) and 4 multiple system atrophy; limbic-predominant age-related TDP-43 encephalopathy neuropathological changes

SUBMITTER: Wu W 

PROVIDER: S-EPMC12233506 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature