Clinical course, causes of worsening, and outcomes of severe ischemic stroke: A prospective multicenter cohort study.

ABSTRACT:

Background

Severe stroke has high rates of mortality and morbidity. This study aimed to investigate the clinical course, causes of worsening, and outcomes of severe ischemic stroke.

Methods

This prospective, multicenter cohort study enrolled adult patients admitted ≤30 days after ischemic stroke from nine hospitals in China between September 2017 and December 2019. Severe stroke was defined as a score of ≥15 on the National Institutes of Health Stroke Scale (NIHSS). Clinical worsening was defined as an increase of 4 in the NIHSS score from baseline. Unfavorable functional outcome was defined as a modified Rankin scale score ≥3 at 3 months and 1 year after stroke onset, respectively. We performed Logistic regression to explore baseline features and reperfusion therapies assoc

SUBMITTER: Wu S 

PROVIDER: S-EPMC12233928 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature