A naphthalimide derivative exerts potent antiplatelet and antithrombotic activities without a bleeding tendency.

ABSTRACT:

Background

Bleeding is the inherent adverse effect of antiplatelet drugs that has limited their use in the prevention of secondary heart attack and stroke. Thus, finding a novel antiplatelet drug with antithrombotic activities while preserving hemostatic function remains a crucial issue. Here, we screened naphthalimide derivatives that we previously synthesized and identified a novel derivative compound 6, which has a more potent antithrombotic effect and has no effect on bleeding cessation. This study is aimed to determine the antiplatelet mechanism of compound 6 and further test whether compound 6 is a safer and more potent antithrombotic agent.

Methods

Platelet aggregation, flow cytometry and immunoblotting were used to determine the in vitro a

SUBMITTER: Lu WJ 

PROVIDER: S-EPMC12234328 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature