Differentiating <i>Peromyscus leucopus</i> bone marrow-derived macrophages for characterization of responses to <i>Borrelia burgdorferi</i> and lipopolysaccharide.

ABSTRACT: Currently, most tools utilized in host-pathogen interaction studies depend on the use of human or mouse (Mus musculus) cells and tissues. While these species have led to countless breakthroughs in our understanding of infectious disease, there are undoubtedly important biological processes that are missed by limiting studies to these two vertebrate species. For instance, it is well-established that a common deermouse in North America, Peromyscus leucopus, has unique interactions with microbes, which likely shape its ability to serve as a critical reservoir for numerous zoonotic pathogens, including a Lyme disease spirochete, Borrelia burgdorferi. In this work, we expand the immunological toolkit to study P. leucopus biology by performing the first differentiatio

SUBMITTER: Wells CC 

PROVIDER: S-EPMC12234436 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature