PipC affects the virulence of <i>Salmonella enterica</i> serovar <i>Enteritidis</i> and its deletion strain provides effective immune protection in mice.

ABSTRACT:

Background

Salmonellosis caused by Salmonella sp. is a foodborne zoonotic disease that poses a significant threat to public health security. Vaccination is a safe and effective strategy for preventing and controlling Salmonella infections. PipC is a chaperone protein associated with Salmonella invasion proteins which is crucial for bacteria to invade host cells.

Methods

In this study, a ΔpipC mutant strain was generated. Subsequently, we examined the environmental stress tolerance of the mutant strain through in vitro simulation experiments. Moreover, its virulence by employing cell and mouse infection models was investigated. Furthermore, we utilized a mouse model to further explore its potential as an attenuated live vaccine against Sa

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12234537 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature