Shared genetic loci connect cardiovascular disease with blood pressure and lipid traits in East Asian populations.

ABSTRACT:

Introduction

Cardiovascular diseases (CVDs), including myocardial infarction (MI), heart failure (HF), atrial fibrillation (AF), and arrhythmia, are major contributors to global mortality and often share overlapping risk factors and pathophysiological mechanisms. While genome-wide association studies (GWAS) have identified many loci for individual CVDs, the shared genetic architecture across related traits-particularly in East Asian populations-remains underexplored.

Materials and methods

We integrated large-scale GWAS summary statistics from East Asian populations to perform genome-wide and local genetic correlation analyses across four CVD phenotypes and five cardiometabolic traits (blood pressure and lipid levels). Using stratified LD score regression, we assessed tissue-

SUBMITTER: Zhong P 

PROVIDER: S-EPMC12234571 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature